R&D

As a future-oriented business, we are currently seeking to develop the source technology and the novel material for creating anti-aging products. We are trying to find the fundamental cause of aging, and at the moment, the most likely cause for aging is Telomere located at the end of the DNA. We are currently conducting research on Telomerase, the enzyme that can affect the length of Telomere, and are also working to identify a substance and to develop a technology to control the enzyme. We have also studied the effect of melanin on human skin and hair color for a long time, and we are continuously doing research the technology and substance that would enable us to gain fundamental control over it. Once this technology is identified and commercialized, humanity would not have to worry so much about gray hair.

Developing anti-aging and skin regenerating medication through controlling the activity of Telomerase

(Identifying the mechanism behind the activation of Telomerase and the control of proteolysis, and discovering the substance that controls such activities) Aging refers to the loss of vital functions over time, and alongside the physiological change, it can cause various diseases including neurodegenerative diseases and metabolic diseases. The telomere, located at the end of chromosomes, becomes more sensitive to damage to the DNA as you age. While telomerase is needed for the replication of DNA molecules at the end of chromosomes, most somatic cells do not have active telomerase, and the telomere tapers towards one end. It has been observed that for both human and mice, the length of telomere shortens as they age. This, along with the protein degradation system losing its effectiveness as people age, results in the disruption of protein homeostasis. Thus it seems developing a method to control the protein degradation of the Telomerase enzyme would contribute to the research of anti-aging and skin regeneration treatment.

Developing anti-aging and skin regenerating medication through controlling the activity of Telomerase

(Identifying the mechanism behind the activation of Telomerase and the control of proteolysis, and discovering the substance that controls such activities) Aging refers to the loss of vital functions over time, and alongside the physiological change, it can cause various diseases including neurodegenerative diseases and metabolic diseases. The telomere, located at the end of chromosomes, becomes more sensitive to damage to the DNA as you age. While telomerase is needed for the replication of DNA molecules at the end of chromosomes, most somatic cells do not have active telomerase, and the telomere tapers towards one end. It has been observed that for both human and mice, the length of telomere shortens as they age. This, along with the protein degradation system losing its effectiveness as people age, results in the disruption of protein homeostasis. Thus it seems developing a method to control the protein degradation of the Telomerase enzyme would contribute to the research of anti-aging and skin regeneration treatment.

The development of gray-hair/hair-loss solution and hair growth solution through the control of Melanin pigment

(The delay and prevention of gray hair through tyronsinase and KROX20 protein degradation control.) The color of our hair is affected by the pigment called melanin. Aging results in less melanin synthesis, and causes our hair to turn gray then white. Statistically, people’s hair turn gray around the age of forty for both men and women, but the exact time varies from person to person depending on the individual’s melanin synthesis status.

The development of gray-hair/hair-loss solution and hair growth solution through the control of Melanin pigment

(The delay and prevention of gray hair through tyronsinase and KROX20 protein degradation control.) The color of our hair is affected by the pigment called melanin. Aging results in less melanin synthesis, and causes our hair to turn gray then white. Statistically, people’s hair turn gray around the age of forty for both men and women, but the exact time varies from person to person depending on the individual’s melanin synthesis status.

The cause of white hair

Melanin is generated at the organelle called Melanosome which is inside the Melanocyte located at the basal layer of our skin. Most substances in whitening cosmetics repress melanin generation, and this is usually done by repressing the activation of tyrosinase. Thus, it seems that developing a method to control the protein degradation of tyrosinase enzyme would contribute to the development of white hair prevention products and whitening cosmetics.

The cause of white hair

Melanin is generated at the organelle called Melanosome which is inside the Melanocyte located at the basal layer of our skin. Most substances in whitening cosmetics repress melanin generation, and this is usually done by repressing the activation of tyrosinase. Thus, it seems that developing a method to control the protein degradation of tyrosinase enzyme would contribute to the development of white hair prevention products and whitening cosmetics.